史向阳教授

史向阳，1970年8月生，化学化工与生物工程学院，生物科学与技术研究所教授，博士生导师，校特聘教授。2008年回国前，在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员，上海市生物物理学会理事，美国密歇根大学医学和生物科学纳米技术研究所客座研究员，首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology）。是American Journal of Nanotechnology, Advances in Nano Research, An International Journal, Journal of Modern Textile Science and Engineering等期刊的编委，也是Nat. Nanotechnol.、Nat.Commun.和 J. Am. Chem. Soc.等84个国际杂志审稿人。

研究方向:

1.生物纳米技术：以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台，研究各种癌症的早期诊断和治疗。

2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中的应用。

3.静电纺纳米纤维在生物医学和环境科学中的应用。

荣誉及获奖情况：

1. 2009年入围首批SCOPUS寻找未来科学之星活动全国纳米科学前10名；

2. 2010年获首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology）”称号

3. 2011年获教育部“新世纪优秀人才”支持计划。

4. 2014年，第五届中国侨界贡献奖创新人才奖。

5. 2014年，中国纺织工程学会第15届陈维稷优秀论文奖。

主持与承担主要项目情况：

1.利用树状大分子纳米技术构建多功能纳米杂化颗粒及其肿瘤CT/MRI双模态成像诊断研究，国家自然科学基金面上项目 (项目批准号：21273032)，2013.1-2016.12，项目主持人，在研。

2.多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究，国家自然科学基金面上项目 (项目批准号：20974019)，2010.1-2012.12，项目主持人，结题。

3.多功能杂化纳米水凝胶及其双模态分子影像学应用，中德科学基金研究交流中心(GZ899)，2013.10-2016.9，项目主持人，在研。

4.树状大分子纳米材料及其医学应用，教育部新世纪人才支持计划，2012.1 -2014.12，项目主持人，结题。

5.多功能树状大分子包裹的纳米金颗粒作为肿瘤CT成像造影剂的研究，上海市科委浦江人才计划（09PJ1400600），2009.7-2011.7，项目主持人，结题。

6.多功能磁性氧化铁/金核壳纳米探针的构建及其分子影像诊断应用，上海市科委纳米专项（11nm0506400），2011.12 -2014. 9，项目主持人, 结题。

7.基于树状大分子的多功能肿瘤成像造影剂的研究, 2008.6-2011.6，项目主持人，已结题。

8.纳米生物医用材料与技术，2014.1-2016.12，项目主持人，在研。

9.葡萄牙马德拉大学“邀请纳米技术主任”基金 (由葡萄牙科技部FCT和Santander 银行资助) ，项目主持人，2010-2018，在研。

10.DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors，葡萄牙科技部 (FCT)项目（PTDC/CTM-NAN/1748/2012）, 2013.4-2015.4, 项目主持人，在研。

11.人工纳米生物机器构筑与生物医学应用的基础研究，973计划（2007CB936000），2007.7-2011.8，参与，已结题。

12.有机/无机纳米复合修复材料及其口腔医学应用开发，国家高技术研究发展计划 (2012AA030309)，2012.1-2014.12，参与，已结题。

发表论著情况：

史向阳教授的主要研究成果包括在纳米医学与生物技术、纳米科学、材料化学、高分子化学和分析化学等领域内共发表或接受发表了206篇期刊论文，9篇书的章节，和183篇会议论文、摘要或报告，并申请了82项专利，授权专利41项。研究工作发表在Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Small, Adv. Funct. Mater.和Biomaterials等等专业杂志上。其中SCI收录的论文有182篇，影响因子超过3.0以上的文章有131篇，影响因子超过7.0以上的文章有28篇。文章总引用数超过5493次，单篇引用最高次数为333次，H-index为42，ESI论文12篇。。

2010年以来发表的代表论著：

1.Hong Yang, Cuixia Zhang,Xiangyang Shi,He Hu, Xiaoxia Du,Yong Fang, Yanbin Ma,Huixia Wu, Shiping Yang. Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. Biomaterials 2010, 31, 3667–3673 (impact factor 8.312, citation #77).

2.Hong Yang, Yeming Zhuang, He Hu, Xiaoxia Du, Cuixia Zhang, Xiangyang Shi, Huixia Wu, and Shiping Yang . Silica-Coated Manganese Oxide Nanoparticles as a Platform for Targeted Magnetic Resonance and Fluorescence Imaging of Cancer Cells. Adv. Funct. Mater. 2010, 20, 1733–1741 (impact factor 10.439, citation #84).

3.Shili Xiao, Mingwu Shen, Rui Guo, Qingguo Huang, Shanyuan Wang, Xiangyang Shi*. Fabrication of Multiwalled Carbon Nanotube-Reinforced Electrospun Polymer Nanofibers Containing Zero-Valent Iron Nanoparticles for Environmental Applications. J. Mater. Chem. 2010, 20, 5700-5708 (impact factor 6.626, citation #40).

4.Mingwu Shen and Xiangyang Shi*. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale 2010, 2, 1596–1610 (citation #59, impact factor 6.739).

5.Hui Liu, Han Wang, Rui Guo, Xueyan Cao, Jinglong Zhao, Yu Luo, Mingwu Shen, Guixiang Zhang, and Xiangyang Shi. Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications. Polym. Chem. 2010, 1 (10), 1677 – 1683 (citation #35, impact factor 5.368).

6.Ruiling Qi, Rui Guo, Mingwu Shen, Xueyan Cao, Leqiang Zhang, Jiajia Xu, Jianyong Yu, Xiangyang Shi*. Electrospun Poly(lactic-co-glycolic acid)/Halloysite Nanotube Composite Nanofibers for Drug Encapsulation and Sustained Release. J. Mater. Chem. 2010, 20, 10622–10629 (impact factor 6.626, citation #62).

7.Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988 (impact factor 8.312, citation #85).

8.Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, and Xiangyang Shi, Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329 (citation #74, impact factor 8.312).

9.Xu Fang, Hui Ma, Shili Xiao, Mingwu Shen, Rui Guo, Xueyan Cao, and Xiangyang Shi*. Facile Immobilization of Gold Nanoparticles into Electrospun Polyethyleneimine/Polyvinyl Alcohol Nanofibers for Catalytic Applications. J. Mater. Chem. 2011, 21 (12), 4493 - 4501 (impact factor 6.626, citation #60).

10.Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Enhanced X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles Complexed with Diatrizoic Acid. J. Mater. Chem. 2011, 21 (13), 5120 - 5127 (citation #27, impact factor 6.626).

11.Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747. (impact factor 6.739, citation #18)

12.Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai, Xiangyang Shi,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles. Biomaterials 2011, 32 (20), 4584-4593 (citation #58, impact factor 8.312).

13.Yin Wang, Xueyan Cao, Rui Guo, Mingwu Shen, Mengen Zhang, Meifang Zhu, and Xiangyang Shi*. Targeted delivery of doxorubicin into cancer cells using a folic acid-dendrimer conjugate. Polym. Chem. 2011, 2 (8), 1754-1760 (citation #39, impact factor 5.368).

14.Chen Peng, Linfeng Zheng, Qian Chen, Mingwu Shen, Rui Guo, Han Wang, Xueyan Cao, Guixiang Zhang,* Xiangyang Shi*. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012, 33, 1107-1119 (impact factor 8.312, citation #87).

15.Yuebin Shan, Ting Luo, Chen Peng, Ruilong Sheng, Amin Cao,* Xueyan Cao, Mingwu Shen, Rui Guo, Helena Tomás, Xiangyang Shi*. Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials 2012, 33, 3025-3035 (impact factor 8.312, citation #50).

16.Yunpeng Huang, Hui Ma, Shige Wang, Mingwu Shen,* Rui Guo, Xueyan Cao, and Xiangyang Shi*. Efficient catalytic reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun polymer nanofibers. ACS Appl. Mater. Interfaces 2012, 4(6), 3054-3061 (impact factor 5.900, citation #22).

17.Hongdong Cai, Kangan Li, Mingwu Shen*, Shihui Wen, Yu Luo, Chen Peng, Guixiang Zhang*, Xiangyang Shi*. Facile assembly of Fe3O4@Au core-shell nanoparticles for dual mode magnetic resonance and computed tomography imaging applications. J. Mater. Chem. 2012, 22, 15110–15120 (impact factor 6.626, citation #26).

18.Chen Peng, Kangan Li, Xueyan Cao, Tingting Xiao, Wenxiu Hou, Rui Guo, Mingwu Shen, Guixiang Zhang**, and Xiangyang Shi*. Facile Formation of Dendrimer-Stabilized Gold Nanoparticles Modified with Diatrizoic Acid for Enhanced Computed Tomography Imaging Applications. Nanoscale 2012, 4 (21), 6768 - 6778 (impact factor 6.739, citation #16, back cover of the issue).

19.Shige Wang, Rita Castro, Chenlei Song, Yu Luo, Mingwu Shen, Helena Tomás**, Meifang Zhu, Xiangyang Shi*. Electrospun laponite-doped poly(lactic-co-glycolic acid) nanofibers for osteogenic differentiation of human mesenchymal stem cells. J. Mater. Chem. 2012, 22, 23357–23367 (impact factor 6.626, citation #13, inside back cover of the issue).

20.Shige Wang, Fuyin Zheng, Yunpeng Huang, Yuting Fang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Encapsulation of Amoxicillin within Laponite-Doped Poly(lactic-co-glycolic acid) Nanofibers: Preparation, Characterization and Antibacterial Activity. ACS Appl. Mater. Interfaces 2012, 4, 6393?6401 (impact factor 5.900, citation #20).

21.Han Wang, Linfeng Zheng, Chen Peng, Mingwu Shen,Xiangyang Shi*, Guixiang Zhang.* Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. Biomaterials 2013, 34, 470-480 (impact factor 8.312, citation #27).

22.Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials 2013, 34, 1402-1412 (impact factor 8.312, citation #19).

23.Shihui Wen, Kangan Li, Hongdong Cai, Qian Chen, Yunpeng Huang, Chen Peng, Mingwu Shen, Guixiang Zhang*,andXiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications. Biomaterials 2013, 34, 1570-1580 (impact factor 8.312, citation #44).

24.Fuyin Zheng, Shige Wang, Mingwu Shen,* Meifang Zhu, Xiangyang Shi*. Antitumor efficacy of doxorubicin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Polym. Chem., 2013, 4(4), 933-941 (impact factor 5.368, back cover of the issue, citation #28).

25.Hui Liu, Yanhong Xu, Shihui Wen, Jingyi Zhu, Linfeng Zheng, Mingwu Shen, Jinglong Zhao, Guixiang Zhang* and Xiangyang Shi*. Facile hydrothermal synthesis of low generation dendrimer-stabilized gold nanoparticles for in vivo computed tomography imaging applications. Polym. Chem. 2013, 4 (6), 1788 - 1795 (impact factor 5.368, Inside front cover of the issue, citation #19).

26.Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces 2013, 5 (5), 1722–1731 (impact factor 5.900, citation #21).

27.Qian Chen, Kangan Li , Shihui Wen, Hui Liu, Chen Peng, Hongdong Cai, Mingwu Shen, Guixiang Zhang**, Xiangyang Shi*. Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 2013, 34, 5200-5209 (impact factor 8.312, citation #31).

28.Hui Liu, Yanhong Xu, Shihui Wen, Qian Chen, Linfeng Zheng, Mingwu Shen, Jinglong Zhao, Guixiang Zhang,* and Xiangyang Shi*. Targeted Tumor Computed Tomography Imaging Using Low Generation Dendrimer-Stabilized Gold Nanoparticles. Chem. Eur. J. 2013, 19, 6409- 6416 (Impact factor 5.696, citation #24).

29.Chen Peng, Jinbao Qin, Benqing Zhou, Qian Chen, Mingwu Shen, Meifang Zhu, Xinwu Lu*, Xiangyang Shi*. Targeted Tumor CT Imaging Using Folic Acid-Modified PEGylated Dendrimer-Entrapped Gold Nanoparticles. Polym. Chem. 2013, 4 (16), 4412 - 4424 (impact factor 5.368, citation #7).

30.Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials 2013, 34, 8382-8392 (impact factor 8.312, citation #22).

31.Shihui Wen, Hui Liu, Hongdong Cai, Mingwu Shen,Xiangyang Shi*. Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes. Adv. Healthcare Mater. 2013, 2, 1267–1276 (impact factor 4.880, citation #15, Front cover of the issue).

32.Dina Maciel, Priscilla Figueira, Shili Xiao, Dengmai Hu, Xiangyang Shi, Joao Rodrigues, Helena Tomás,* Yulin Li*. Redox-responsive Alginate Nanogels with Enhanced Anticancer Cytotoxicity. Biomacromolecules 2013, 14, 3140-3146 (Impact factor 5.788, citation #8).

33.Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces 2013, 5(20), 10357-10366 (impact factor 5.900, citation #7).

34.Hui Liu, Xiaoming Cao, Jianmao Yang, Xue-Qing Gong,* and Xiangyang Shi*. Dendrimer-Mediated Hydrothermal Synthesis of Ultrathin Gold Nanowires. Sci. Rep. 2013, 3, 3181 (DOI:10.1038/srep03181, impact factor 5.078).

35.Zhiguo Zhou, Bin Kong, Chao Yu, Xiangyang Shi*, Mingwei Wang, Wei Liu, Yanan Sun, Yingjian Zhang, Hong Yang, and Shiping Yang*.Tungsten Oxide Nanorods: An Efficient Nanoplatform for Tumor CT Imaging and Photothermal Therapy. Sci. Rep. 2014, 4, 3653 (DOI:10.1038/srep03653, impact factor 5.078, citation # 6). AuDES

36.Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials 2014, 35 3666-3677 (impact factor 8.312, citation #10).

37.Shige Wang, Jingyi Zhu, Mingwu Shen, Meifang Zhu,Xiangyang Shi*. Poly(amidoamine) Dendrimer-Enabled Simultaneous Stabilization and Functionalization of Electrospun Poly(γ-glutamic acid) Nanofibers. ACS Appl. Mater. Interfaces 2014, 6, 2153?2161 (impact factor 5.900, citation # 1).

38.Mara Goncalves, Dina Maciel, Débora Capêlo, Shili Xiao, Wenjie Sun, Xiangyang Shi, Joao Rodrigues, Helena Tomás,* Yulin Li*. Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging. Biomacromolecules 2014, 15, 492?499 (Impact factor 5.788, citation # 3).

39.Hui Liu, Han Wang, Yanhong Xu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang*, Xiangyang Shi*. Synthesis of PEGylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications. Nanoscale 2014, 6(9), 4521-4526 (impact factor 6.739, citation #3).

40.Hui Liu+, Han Wang, Yanhong Xu, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces 2014, 6, 6944?6953 (impact factor 5.900, citation # 4).

41.Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*.Targeted Cancer Theranostics Using Alpha-Tocopheryl Succinate-Conjugated Multifunctional Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2014, 35, 7635-7646 (impact factor 8.312, citation # 2).

42.Kai Li, Shige Wang, Shihui Wen, Yueqin Tang, Jipeng Li,Xiangyang Shi,* and Qinghua Zhao*. Enhanced In Vivo Antitumor Efficacy of Doxorubicin Encapsulated within Laponite Nanodisks. ACS Appl. Mater. Interfaces 2014, 6, 12328?12334 (impact factor 5.900, citation # 1).

43.Guoying Wang, Dina Maciel, Yilun Wu, Jo?o Rodrigues,Xiangyang Shi, Yuan Yuan, Changsheng Liu, Helena Tomás,* Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery. ACS Appl. Mater. Interfaces 2014, 6, 16687?16695 (impact factor 5.900).

44.Fanfan Fu, Jingyi Zhu, Shihui Wen, Mingwu Shen, Xiangyang Shi*. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: Investigating the role played by PEG spacer. ACS Appl. Mater. Interfaces 2014, 6, 16416?16425 (impact factor 5.900).

45.Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces 2014, 6, 17190-17199 (impact factor 5.900).

46.Shihui Wen, Qinghua Zhao, Xiao An, Jingyi Zhu, Wenxiu Hou, Kai Li, Yunpeng Huang, Mingwu Shen, Wei Zhu*, Xiangyang Shi*. Multifunctional PEGylated Multiwalled Carbon Nanotubes for Enhanced Blood Pool and Tumor MR Imaging. Adv. Healthcare Mater. 2014, 3, 1568-1577 (Impact factor 4.880, citation #1).NSFC

47.Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 8.312).

48.Shili Xiao, Rita Castro, Jo?o Rodrigues, Xiangyang Shi, Helena Tomás*. PAMAM dendrimer/pDNA functionalized-magnetic iron oxide nanoparticles for gene delivery. J. Biomed. Nanotechnol. 2015, 11, 1370-1384 (impact factor 7.578).

49.Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2014, DOI: 10.1016/j.progpolymsci.2014.08.002 (Impact factor 26.854).

国际交流与合作：

美国密歇根大学（University of Michigan, Ann Arbor），美国乔治亚大学格里芬分校（University of Georgia, Griffin），美国伊利诺伊大学芝加哥分校（University of Illinois at Chicago），葡萄牙马德拉大学 (Universidade da Madeira)，匈牙利徳布勒森大学（University of Debrecen），德国亚琛工业大学（RWTH Aachen）。

主讲课程：

纳米医学 (博士研究生课程)，纳米医学与生物技术（功能材料专业生物材料方向本科生课程）。

博士后和研究生招生信息：

欢迎感兴趣的具有化学、化工、生物医学、材料、纺织等相关研究背景的博士生申请博士后研究职位，同时欢迎感兴趣的具有相同背景的本科生和硕士生报考加入本课题组。

联系电话：021-67792656          EMAIL：xshi@dhu.edu.cn